Skin aging, especially in the face, is associated with a progressive increase in sagging tissues and a reduction in elasticity. In menopausal and postmenopausal women, estrogen administration increases collagen content, dermal thickness and elasticity, while decreasing aging dry skin.
The combination of E3 (Estriol) with therapeutic dosages of Vitamin A (Retinol) is clinically proven to nurture collagen development, increase elastin levels, improve hydration and support healthy, vibrant skin cell development in women with mature skin, (age 40+).
E3 provides the additional benefit of reducing menopausal symptom without accumulating in the body.
What is Estriol?
Estriol is a weak estrogen when systemically administered, but it can induce potent anti-aging effects as a topical treatment. A six-month study of peri- and postmenopausal women was conducted at the University of Vienna in Austria comparing the topical application of estriol and estradiol creams. The doctors found that skin symptoms of aging improved, and that those treated with estriol obtained superior results, with no systemic hormonal side effects noted.
In a study published in February 2007, a group of women who were already taking oral estrogen drugs were given a topical 0.01% estrogen cream. After only four months, both dermal and epidermal thickness was enhanced, as were dermal collagen levels. This study showed that topical estrogen application provided rapid and definitive anti-aging effects even in women who had high systemic estrogen blood levels. The significance of this study is that it shows how quickly a small amount of estrogen delivered directly into the skin induces profound anti-aging effects.
What is Retinol, Vitamin A?
The vitamin A form found in fruits and vegetables is called ‘provitamin A carotenoid’ (e.g. beta-carotene), which can be converted into retinolin the body.
Retinol is a form of retinoid, a derivative of vitamin A. It’s commonly used to give your skin a healthy boost by minimizing fine lines and wrinkles, smoothing texture, and diminishing hyper pigmentation and dark spots.
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